周斌 (中国细胞生物学学会创新奖——杰出成就奖获得者)

研究员 
中国科学院分子细胞科学卓越创新中心

报告题目：谱系示踪技术与器官发育再生研究

周斌研究员现任中国科学院分子细胞科学卓越创新中心研究组长。2002年毕业于浙江大学医学院临床医学系获得MD，2006年毕业于中国医学科学院中国协和医科大学获得PhD，2006年至2010年在美国哈佛大学医学院波士顿儿童医院从事博士后研究。2010年9月起至今在中国科学院担任研究员，研究组长。主要建立细胞谱系示踪新技术，并利用新技术研揭示发育、疾病、再生过程中的细胞分化、增殖、衰老等细胞命运过程，并阐明细胞命运调控的分子机制，为相关疾病治疗提供重要理论基础和新的研究方向，解决了领域内多个重要科学问题。代表性研究工作发表在Cell、Nature、Science等国际学术期刊，其中发现哺乳动物新生期心脏具有重新生成冠状动脉的能力的成果入选“中国科学十大进展”；创建的谱系示踪新技术解决了国际心脏研究领域内关于心脏干细胞与心肌再生的争议问题；建立了双重组酶介导的遗传学技术和邻近细胞遗传学技术，从全新的角度揭示了器官发育与修复再生的调控机制。曾获得国际心脏研究会—“杰出研究员奖”、国家杰出青年科学基金、中国青年科技奖、谈家桢生命科学创新奖、科学探索奖、新基石研究员等。现任中国科学•生命科学编委，Circulation Research编委，Journal of Hepatology编委等。

Professor Bin Zhou currently serves as the head of a research group at the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences. He graduated with an MD from Zhejiang University School of Medicine in 2002 and obtained his PhD from Peking Union Medical College, Chinese Academy of Medical Sciences, in 2006. From 2006 to 2010, he conducted postdoctoral research at Boston Children's Hospital, Harvard Medical School. Since September 2010, he has been a researcher and group leader at the Chinese Academy of Sciences.

His primary focus is on establishing new cell lineage tracing technologies and utilizing these advancements to reveal cellular fates—such as differentiation, proliferation, and senescence—during development, disease, and regeneration processes. He aims to elucidate the molecular mechanisms regulating cell fate, providing important theoretical foundations and new research directions for related disease treatment, and has solved several significant scientific problems in the field. His representative research has been published in international academic journals such as Cell, Nature, and Science. Notably, he discovered that the neonatal mammalian heart possesses the ability to generate de novo coronary arteries, a finding that was selected as one of the "Top Ten Advances in Chinese Science." The lineage tracing technology he developed addressed controversies regarding cardiac stem cells and myocardial regeneration in the cardiac research community. He has also established dual-recombinase-mediated genetic techniques and intercellular genetics methods, which provide new insights into cell fate plasticity and the regulatory mechanisms of organ development and repair regeneration.

He has received numerous awards, including the "Outstanding Investigator Award" from the International Society for Heart Research, the National Distinguished Young Scientist Fund, the China Youth Science and Technology Award, the Tan Jiazhen Life Science Innovation Award, Xplorer Prize, and New Cornerstone Investigator. He currently serves as an editorial board member for Chinese Science Life Sciences, Circulation Research, and Journal of Hepatology, among others.

近五年发表主要论文(2020-2024)

1. Zhao H, Liu Z, Chen H, Han M, Zhang M, Liu K, Jin H, Liu X, Shi M, Pu W, Werner M, Meister M, Kauschke S, Sun R, Wang J, Shen R, Wang Q, Ma X, Tchorz J, Zhou B. Identifying specific functional roles for senescence across cell types. Cell 2024;187:7314-7334.
2. Liu K, Meng X, Liu Z, Tang M, Lv Z, Huang X, Jin H, Han X, Liu X, Pu W, Zhu H, Zhou B. Tracing the origin of alveolar stem cells in lung repair and regeneration. Cell 2024;187:2428-2445.
3. Lv Z, Liu Z, Liu K, Lin X, Pu W, Li Y, Zhao H, Xi Y, Sui P, Vaughan A, Gillich A, Zhou B. Alveolar regeneration by airway secretory cell-derived p63+ progenitors. Cell Stem Cell 2024;31:1685-1700.e6.
4. Li Y, Liu Z, Han X, Liang F, Zhang Q, Huang X, Shi X, Huo H, Han M, Liu X, Zhu H, He L, Shen L, Hu X, Wang J, Wang Q, Smart N, Zhou B, He B. Dynamics of Endothelial Cell Generation and Turnover in Arteries during Homeostasis and Diseases. Circulation 2024;149:135-154.
5. Zhang M, Lui K, Zhou B. Application of New Lineage Tracing Techniques in Cardiovascular Development and Physiology. Circ Res 2024;134:445-458.
6. Guo W, Zhang X, Li L, Shao P, Liang C, Zhang H, Liu K, Wang S, Peng Y, Luo J, Ju Y, De Marzo A, Yu C, Chen L, Zhou B, Gao D. JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination. Nat Genet 2024 10.1038/s41588-024-01979-1.
7. Pu W, Zhu H, Zhang M, Pikiolek M, Ercan C, Li J, Huang X, Han X, Zhang Z, Lv Z, Li Y, Liu K, He L, Liu X, Heim MH, Terracciano L, Tchorz JS, Zhou B. Bipotent transitional liver progenitor cells contribute to liver regeneration. Nat Genet 2023;55(4):651-664. Cover Story.
8. Han M, Z L, Liu L, Huang X, Wang H, Pu W, Wang E, Liu X, Li Y, He L, Li X, Wu J, Qiu L, She R, Wang Q, Ji Y, Ardehali R, Shu Q, Lui KO, Wang L, Zhou B. Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis. Nat Genet 2023;55(4):665-678.
9. Liu K, Jin H, Zhang S, Tang M, Meng X, Li Y, Pu W, Lui K, Zhou B. Intercellular genetic tracing shows the lack of hematopoietic specification from cardiac endothelium in the developing heart. Dev Cell 2023;58(16):1502-1512.
10. Wu J, Zhao H, Tao Y, Yang C, Yang Y, Zhou B, Zhao Y. Improved Factor Combination for In Vivo Reprogramming of Cardiac Myofibroblast to Cardiomyocyte-Like Cell With Dual Recombinase Tracing. Circulation 2023;148:1728-1731.
11. Zhang S, Zhang Q, Liu Z, Liu K, He L, Lui KO, Wang L, Zhou B. Genetic dissection of intercellular interactions in vivo by membrane-permeable protein. PNAS 2023;120(1):e2120582120.
12. Liu K, Tang M, Xu W, Meng X, Jin H, Han M, Pu J, Li Y, Jiao F, Sun R, Shen R, Lui K, Lu L, Zhou B. An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo. PNAS 2013;120(25):e2207210120.
13. Zhang S, Zhao H, Liu Z, Liu K, Zhu H, Pu W, He L, Wang R, Zhou B. Monitoring of cell-cell communication and contact history in mammals. Science 2022;378(6623): eabo5503. PDF
14. Pu W, Zhang M, Liu X, He L, Li J, Han X, Lui KO, He B, Zhou B. Genetic Proliferation Tracing Reveals a Rapid Cell Cycle Withdrawal in Preadolescent Cardiomyocytes. Circulation 2022;145:410-412.
15. Han M, Liu Z, He L, Li X, Liu L, Huang X, Zhang M, Yan Y, Lui KO, Zhou B. Dual Genetic Lineage Tracing Reveals Capillary to Artery Formation in the Adult Heart. Circulation 2022;145:1179-1181.
16. Tang J, Zhu H, Tian X, Wang H, Liu S, Liu K, Zhao H, He L, Huang X, Feng Z, Ding Z, Long B, Yan Y, Smart N, Gong H, Luo Q, Zhou B. Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates. Circ Res 2022;130:352-365. (Cover story)
17. Jin H, Liu K, Huang X, Huo H, Mou J, Qiao Z, He B, Zhou B. Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart. Circ Res 2022;130:1682-1697. (Cover story)
18. He L, Pu W, Liu X, Zhang Z, Han M, Li Y, Huang X, Han X, Li Y, Liu K, Shi M, Lai L, Sun R, Wang Q, Ji Y, Tchorz J, Zhou B. Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science 2021;371:eabc4346.
19. Han X, Zhang Z, He L, Zhu H, Li Y, Pu W, Han M, Zhao H, Liu K, Li Y, Huang X, Zhang M, Jin H, Lv Z, Tang J, Wang J, Sun R, Fei J, Tian X, Duan S, Wang Q, Wang L, He B, Zhou B. A suite of new Dre-recombinase drivers markedly expans the ability to perform intersection genetic targeting. Cell Stem Cell 2021;28:1-17
20. Zhao H, Huang X, Liu Z, Pu W, Lv Z, He L, Li Y, Zhou Q, Lui KO, Zhou B. Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas. Nat Metab 2021;3(3):352-365.
21. Wang H, Zhao H, Zhu H, Li Y, Tang J, Li Y, Zhou B. Sca1+ Cells Minimally Contribute to Smooth Muscle Cells in Atherosclerosis. Circ Res 2021;128:133-135.
22. Liu X, Pu W, He L, Li Y, Zhao H, Li Y, Liu K, Huang X, Weng W, Wang Q-D, Shen L, Zhong T, Sun K, Ardehali R, He B, Zhou B. Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle. Nat Commun 2021;12(1):5784.
23. Jin H, Liu K, Tang J, Huang X, Wang H, Zhang Q, Zhu H, Li Y, Pu W, Zhao H, He L, Li Y, Zhang S, Zhang Z, Zhao Y, Qin Y, Pflanz S, Kasmi K, Zhang W, Liu Z, Ginhoux F, Ji Y, He B, Wang L, Zhou B. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nat Commun 2021; 12(1): 2863.
24. Zhang S, Li Y, Huang X, Liu K, Wang QD, Chen AF, Sun K, Lui KO, Zhou B*. Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells During Cardiac Fibrosis. Circulation 2021;144:2004-2020.
25. Tang J, Wang H, Huang X, Li F, Zhu H, Li Y, He L, Zhang H, Pu W, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Tian X, Zhang L, Gao D, Zhou B. Arterial Sca1+ Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration. Cell Stem Cell 2020;26:81-96.e4. PDF
26. Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020;54:593-607.e5. (Featured Article) PDF
27. He L, Nguyen NB, Ardehali R, Zhou B. Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress. Circulation 2020;142:275-291.
28. Pu W, Han X, He L, Li Y, Huang X, Zhang M, Lv Z, Yu W, Wang QD, Cai D, Wang J, Sun R, Fei J, Ji Y, Nie Y, Zhou B. A genetic system for tissue-specific inhibition of cell proliferation. Development 2020;147:dev183830.
29. Tian X, He L, Liu K, Pu W, Zhao H, Li Y, Liu X, Tang M, Sun R, Fei J, Ji Y, Qiao Z, Lui KO, Zhou B. Generation of a self-cleaved inducible Cre recombinase for efficient temporal genetic manipulation. EMBO J 2020;39:e102675. Covery Story.
30. Zhao H, Li Y, He L, Pu W, Yu W, Li Y, Wu YT, Xu C, Wei Y, Ding Q, Song BL, Huang H, Zhou B. In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia. Circulation 2020;141:67-79.