分会场

召集人

Xuebiao Yao
University of Science and Technology of China

Ye-Guang Chen
Nanchang University

邀请报告人
  • Xuebiao Yao，University of Science and Technology of China
  • Ye-Guang Chen，Nanchang University
  • Ye-Guang Chen，Nanchang University
    Introduction
  • Alpha Yap，University of Queensland, Australia
  • Akira Sawaguchi，University of Miyazaki, Japan
  • Jennifer Zenker，Monash University, Australia
    Pluripotency - a microtubule cytoskeleton regulated state?
  • Kyung Ku Jang，Yonsei University, South Korea
  • Zhengjun Chen，Kunming University of Science and Technology
    Unveiling a Novel Liver-Resident Monocyte Subset: Its Contribution to Hepatic Macrophage Homeostasis and Plasticity
  • Jinwook Choi，GIST, South Korea
本分会场致力于探讨类器官技术的前沿发展及组织特异性环境下细胞可塑性的动态特征。我们汇聚领域内的杰出科学家，共同探索三维组织工程学前沿以及复杂微环境中的细胞行为研究。

本分会场特别欢迎干细胞生物学、组织工程学、发育生物学和再生医学领域的研究人员参与。我们为资深研究者和青年科学家提供了良好的交流平台，以促进类器官研究和细胞可塑性领域的思想交流与合作创新。
This session focuses on cutting-edge developments in organoid technology and the dynamic nature of cellular plasticity within tissue-specific contexts. The session brings together leading researchers exploring the frontier of three-dimensional tissue engineering and cellular behavior in complex microenvironments.

This session will be of particular interest to researchers in stem cell biology, tissue engineering, developmental biology, and regenerative medicine. It provides an excellent platform for both established investigators and early-career scientists to exchange ideas and forge new collaborations in the field of organoid research and cellular plasticity.
召集人

苏文静
浙江大学

赵林桔
四川大学华西医院

邀请报告人
  • 苏文静，浙江大学
    BMP通路失活驱动晚期前列腺癌耐药及转移的分子机制
  • 赵林桔，四川大学华西医院
    胶质瘤肿瘤微环境和靶向治疗
  • 王平，同济大学医学院
    氨基酸感应机制与肿瘤治疗
  • 邝栋明，中山大学生命科学学院
    肿瘤治疗与免疫微环境互作机制
  • 李颜，南京大学模式动物研究所（中国细胞生物学学会-碧云天青年科学家奖入围者）
    Decoding human specific tumor microenvironment with human immune system (HIS) mice
本次中国细胞生物学学会年会WLLA论坛以"肿瘤微环境"为主题，旨在深入探讨肿瘤微环境在癌症研究领域的前沿进展及未来发展方向。肿瘤微环境作为肿瘤发生发展的"沃土"，其复杂的成分组成和动态变化特性，对肿瘤的生长、侵袭、转移以及治疗反应起着决定性作用。论坛将重点聚焦以下研究方向：1）肿瘤微环境中各类细胞成分（包括免疫细胞、癌相关成纤维细胞、内皮细胞、间充质细胞等）与肿瘤细胞之间的信号通路网络及其调控机；2）肿瘤微环境中细胞外基质重塑、代谢重编程、免疫逃逸、血管生成等关键生物学过程，以及这些过程在肿瘤进展中的作用机制；3）基于肿瘤新抗原免疫识别与微环境调控在在免疫治疗、靶向治疗等方面的创新策略；4）肿瘤微环境在药物递送、耐药机制及其克服策略等方面的最新研究进展。作为促进青年学者成长的重要平台，本次论坛将采用主题报告的形式，通过多学科交叉的视角，鼓励深入交流与思想碰撞。我们期待通过凝聚新生代研究力量，促进跨领域合作，为肿瘤微环境研究注入新活力，推动该领域向更广阔的方向发展。
The WLLA Forum at the 2025 Annual Meeting of Chinese Society for Cell Biology focuses on "Tumor Microenvironment," aiming to explore cutting-edge advances and future directions in cancer research through the lens of tumor microenvironment. Serving as the "fertile soil" for tumor development, the tumor microenvironment, with its complex composition and dynamic nature, plays a pivotal role in tumor growth, invasion, metastasis, and therapeutic response.
The forum will specifically concentrate on the following research directions: 1) The signaling network and regulatory mechanisms between various cellular components within the tumor microenvironment (including immune cells, cancer-associated fibroblasts, endothelial cells, and mesenchymal cells) and tumor cells; 2) Key biological processes in the tumor microenvironment, such as extracellular matrix remodeling, metabolic reprogramming, immune evasion, and angiogenesis, as well as their mechanistic roles in tumor progression; 3) Therapeutic approaches integrating tumor neoantigen recognition and microenvironment regulation for enhanced immunotherapy and targeted treatment; 4) Latest research advances in drug delivery, resistance mechanisms, and strategies to overcome these challenges within the tumor microenvironment. As a vital platform fostering the growth of young scholars, this forum will feature keynote presentations that encourage in-depth exchange and intellectual discourse through an interdisciplinary perspective. By bringing together young researchers, we aim to promote cross-field collaboration, inject new vitality into tumor microenvironment research, and drive the field toward broader horizons.
召集人

Peng Xia
Zhejiang University

Jingyan Fu
China Agricultural University

邀请报告人
  • Peng Xia，Zhejiang University
    Mechanical feedback and architectural dynamics drive robust collective cell spreading
  • Jingyan Fu，China Agricultural University
    Centriole and polo activity collectively mediate the organization of pericentriolar material
  • Andrea Musacchio，Max Planck Institute of Molecular Physiology (The EMBO Keynote Lecture)
  • Laura Machesky，University of Cambridge
  • Xing Liu，University of Science and Technology of China
    Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation
  • Liangyu Zhang，University of California, Berkeley
    Regulation of meiotic recombination by phase separation
  • Zhixing Chen，Peking University
    Gentle and bright dyes for imaging organelle dynamics
  • Chuanhai Fu，University of Science and Technology of China
    Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly
  • Changlu Tao，University of Science and Technology of China / Shenzhen Institute of Advanced Technology, CAS
    “Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling
  • Zhenghong Zhou，Dept of Microbiology, University of California,Los Angeles (UCLA), USA
    Molecular sociology of virus-induced cellular condensates
这个专题由来自中国、英国、美国的学者介细胞器动力学的前沿研究。细胞动力学是一门新兴的交叉性学科, 量化研究生命活动功能蛋白机器与细胞器分子时空动力学特征与调控规律。
This special topic is presented by scholars from China, the United Kingdom, and the United States, focusing on cutting-edge research in organelle dynamics. Organelle dynamics is an emerging interdisciplinary field that quantitatively studies the spatiotemporal dynamics and regulatory mechanisms of protein machinery and organelles.
召集人

杜鹏
北京大学

王强
华南理工大学

邀请报告人
  • 杜鹏，北京大学
    从发育的角度对肝母细胞瘤进行时空解析
  • 王强，华南理工大学
  • 王红梅，中国科学院动物研究所
  • 罗振革，上海科技大学
    Human neuron maturation and axon regeneration: rejuvenated state enables neuronal complexity and neuronal repair
  • 景乃禾，广州实验室
    Gastrula-premarked posterior enhancer primes posterior tissue development
  • 赵允，中国科学院分子细胞科学卓越创新中心
    Gli在多种组织器官中的功能研究
  • 陈捷凯，中国科学院广州生物医药与健康研究院
    利用类脑器官溯源KABUKI神经谱系发育异常机制
  • 李伟，中国科学院动物研究所
    哺乳动物工程生物学基础与转化
  • 陈静，四川大学华西医院
    胚胎体轴建立的关键信号及分子开关
胚胎发育是一个复杂的过程，涉及细胞分化、组织形成和器官发育。自组织是指内在信号和相互作用驱动下，自发形成有序结构和功能的过程。重构则是指在发育过程中，细胞和组织通过分裂、迁移和死亡等方式，不断调整和优化自身的结构，以适应发育的需要。这两个过程共同推动胚胎从单一细胞发展成为复杂的多细胞生物体。自组织和重构是胚胎发育中的关键机制，它们确保了生物体的形态和功能的精确构建。
在研究中，类囊胚和类器官是模拟早期胚胎结构或器官发育的有效模型。类囊胚是由干细胞生成的类似囊胚的结构，提供了对早期胚胎发生的见解，而类器官则提供了一个研究器官形成和疾病的体外系统。这两种模型为人类早期胚胎发育及组织器官形成的生理和病理学研究提供了革命性视角，深刻影响了细胞生物学、发育生物学、肿瘤学、再生医学和临床医学等多个科学领域，提高了人类对生命、疾病和治疗的理解。
Embryonic development is a complex process that involves cell differentiation, tissue formation, and organ development. Self-organization refers to the process where ordered structures and functions spontaneously emerge under the drive of internal signals and interactions. Remodeling, on the other hand, refers to the ongoing adjustments and optimizations of cell and tissue structures through division, migration, and death to meet the needs of development. These two processes work together to propel the embryo from a single cell to a complex multicellular organism. Self-organization and remodeling are key mechanisms in embryonic development, ensuring the precise construction of the organism's form and function.
In research, blastoids and organoids serve as effective models for simulating early embryonic structures or organ development. Blastoids are structures resembling blastocysts generated from stem cells, offering insights into early embryonic events. Similarly, organoids provide a platform for studying organ formation and diseases. These two models have revolutionized the study of human early embryonic development and the formation of tissues and organs, profoundly impacting various scientific fields such as cell biology, developmental biology, oncology, regenerative medicine, and clinical medicine. They have enhanced human understanding of life, disease, and treatment.
召集人

何志颖
同济大学附属东方医院

潘国宇
上海微知卓生物科技有限公司

邀请报告人
  • 何志颖，同济大学附属东方医院
    干细胞活体示踪及基于游离DNA检测的干细胞临床药代动力学研究
  • 潘国宇，上海微知卓生物科技有限公司
    MSC在肝损伤中的疗效和细胞动力学
  • 崔俊，沙砾生物科技有限公司
    细胞治疗产品早期临床中的PK研究及模型探索
  • 周芳，中国药科大学
    细胞药代动力学导向的间充质干细胞重塑狼疮肾脏微环境的机制研究
  • 李洪贞，北京昭衍新药研究中心股份有限公司
    关于细胞治疗产品药动学研究中生物分析技术的考虑
  • 杨敏，江苏省原子医学研究所
    基于核分子影像的细胞药物在体示踪技术研发及转化
  • 汪溪洁，国家上海新药安全评价研究中心/ 上海益诺思生物技术股份有限公司
    细胞治疗产品非临床药代动力学评价策略和案例分享
  • 赵玉政，华东理工大学
    细胞代谢示踪与生命健康
细胞新药研发正加速推进。近些年，Car-T的药代动力学有了较快的进展。但随着TIL等多种免疫细胞相继被批准上市，我们对于这些新的免疫细胞的药代动力学尚缺乏认识。此外，对于干细胞药物，由于缺乏与宿主区分的特异性分子标志物，临床缺乏可用的检测技术，导致临床药代动力学数据缺乏，使得干细胞毒性、疗效、机制的评价难以实现，成为目前干细胞药物研发的一大困境。因此，开发临床可用的检测方法，开展细胞药物在人体内分布、存续等药代动力学研究，是细胞药物研发领域亟待解决的重大问题。本会场旨在召集近两年本领域做出突出成绩的知名学者及青年PI分享最新研究成果，促进细胞治疗药代动力学方案的建立和推广。
The development of new cell drugs is accelerating. In recent years, the pharmacokinetics of Car-T has made rapid progress. However, as various immune cell therapies, such as TIL, have gained approval for clinical use, our understanding of the pharmacokinetics of these novel immune cells remains limited. Moreover, stem cell therapies face additional challenges. The lack of specific cell drug biomarkers and reliable clinical detection technologies limited clinical pharmacokinetic research. This makes it difficult to evaluate the toxicity, efficacy, and mechanisms of stem cell-based therapies, posing a major obstacle in their development. To address these challenges, there is an urgent need to develop clinically viable detection methods and to conduct pharmacokinetic studies focused on the distribution and persistence of cell drugs within the human body. This venue aims to bring together renowned scholars and promising young PIs who have made significant contributions to the field over the past two years. By sharing the latest research findings, we hope to promote the development and implementation of pharmacokinetic programs for cell therapies.
召集人

徐楠杰
上海交通大学医学院

张维绮
中国科学院北京基因组研究所（国家生物信息中心）

邀请报告人
  • 徐楠杰，上海交通大学医学院
    Aberrant switch of competitive post-translational signals for neurodegeneration and aging
  • 张维绮，中国科学院北京基因组研究所（国家生物信息中心）
    Aging Clock and Its Interventions
  • 赵经纬，浙江大学
  • 郑加麟，同济大学
    小胶质细胞谷氨酰胺酶——脑衰老相关疾病干预新靶点
  • 王光辉，苏州大学
    帕金森病神经炎症与多巴胺能神经元损伤
  • 张杰，厦门大学
    神经元衰老在阿尔茨海默病中的作用机制
  • 刘强，天津医科大学
    Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis
  • 孙淑慧，首都医科大学安贞医院
    脊髓衰老机制及干预探究
大脑是处理感觉信息和控制运动的器官，也执行多种高级功能，如语言、学习、思维和情绪。神经系统衰老引起神经功能改变和认知水平下降，并参与神经退行性疾病和痴呆等疾病的发生。尽管我们清楚地观察到衰老的脑改变，但参与这一过程的机制依然不明。本分会场聚焦衰老这一主题，探讨神经系统衰老与疾病，以及干预策略。
Brain is an organ that integrates sensory information and controls movement. It is also involved in intellectual functions, such as speech, learning, thought and emotion. Aging of the central nervous system leads to the decline of neuronal function and cognition, which is tightly associated with neurodegenerative diseases and dementia. Although the brain changes with aging is clear, the mechanism underlying aging process is still largely unknown. Our session focuses on the theme for aging in the central nervous system, exploring the mechanism of brain aging and the strategy of intervention.
召集人

赵呈天
中国海洋大学

谢珊珊
浙江大学医学院附属儿童医院

邀请报告人
  • 谢珊珊，浙江大学医学院附属儿童医院
    原发性纤毛运动障碍的发病机制研究
  • 欧光朔，清华大学生命科学学院
    Hyperactive protein responses and functional residuomics of cilia
  • 陈宇鹏，天津医科大学
  • 朱献军，四川省人民医院
    N6-methyladenosine modification is essential for visual function and cilia genesis in retinal photoreceptor cells
  • 周军，南开大学生命科学学院
    TBC1D20 coordinates vesicle transport and actin remodeling to regulate ciliogenesis
  • 王磊，广州实验室
    吸烟引起的纤毛损伤与慢性阻塞性肺疾病
  • 桂淼，浙江大学
  • 曹木青，上海交通大学基础医学院
    B9D2基因突变导致Joubert综合征和Meckel综合征的机制
纤毛是细胞内关键的细胞器，在细胞分裂、信号转导、极性维持及个体发育等过程中发挥重要作用。作为源于中心体的细胞结构，纤毛的正常功能对于维持细胞稳态至关重要。本分会场将汇聚领域内的领先研究者，深入探讨纤毛的细胞生物学基础，包括其结构特征、装配机制及功能。会议将重点讨论纤毛功能失调与各类疾病（如遗传性纤毛病、肾脏疾病和呼吸系统疾病）的关联。此外，将介绍在纤毛研究中应用的新兴技术及治疗策略，以推动对纤毛及其相关疾病的理解和治疗。
Cilia are essential organelles with critical roles in cell division, signal transduction, polarity maintenance, and development. Originating from the centrosome, cilia are fundamental for cellular homeostasis and function. This session will bring together leading experts to explore the cell biology of cilia, focusing on their structural characteristics, assembly mechanisms, and functional roles. Discussions will include the pathological implications of ciliary dysfunction in various diseases, such as genetic ciliopathies, renal disorders, and respiratory diseases. Additionally, the session will highlight emerging technologies and therapeutic strategies in ciliary research, advancing our understanding and treatment of ciliary-related conditions.
召集人

焦雨铃
北京大学

陈江华
中国科学院西双版纳植物园

邀请报告人
  • 焦雨铃，北京大学
    细胞增殖维持植物干细胞命运的“西西弗斯”调控机制
  • 陈江华，中国科学院西双版纳植物园
    豆科植物中复叶分生组织活性的维持与小叶数目调控
  • 孙蒙祥，武汉大学
    The role of parental-of-origin genes in fertilization and embryogenesis
  • 王佳伟，中国科学院分子植物卓越中心
    植物单细胞转录组测序技术的优化与应用
  • 赵忠，中国科技大学
    调控植物干细胞命运的氧化还原信号
  • 陈浩东，清华大学
    植物感应重力的机理
  • 茶歇，
    15:00-15:05 Dr. Colin Monks，Intelligent Imaging
    Principles and applications of plant gravity growth imaging microscopy
植物固着生长，通过终生维持器官发生的能力适应环境。植物如何维持干细胞、干细胞如何发生器官以及器官如何建立三维形态是在细胞水平理解植物生长发育的基础。本会场聚焦该领域前沿研究进展，重点探讨干细胞的维持与器官发生，利用新技术解析细胞水平发育过程中细胞间的互作与分子调控机制，为农业生物技术提供科学依据与理论支持。
Plants, being sessile organisms, adapt to the environment by maintaining the ability of organogenesis throughout their life cycle. Understanding how plants sustain stem cells, how these stem cells give rise to organs, and how organs acquire three-dimensional shapes serves as the foundation for comprehending plant growth and development at the cellular level. This session focuses on the cutting-edge research advancements in this field, emphasizing the maintenance of stem cells and organogenesis. By leveraging novel technologies, it aims to dissect the intercellular interactions and molecular regulatory mechanisms underlying developmental processes at the cellular level, thereby providing scientific basis and theoretical support for agrobiotechnology.
召集人

李天晴
昆明理工大学

秦建华
中科院大连化学物理研究所

邀请报告人
  • 李天晴，昆明理工大学
    利用胚胎模型简析人着床胚胎发育以及早期器官的发生
  • 秦建华，中科院大连化学物理研究所
    干细胞与类器官工程
  • 尹晓磊，同济大学
    小分子精准调控类器官中细胞命运与细胞集群动态平衡
  • 孙伟，清华大学
    生物3D打印与类器官和器官芯片
  • 沙家豪，南京医科大学
    建立人类类原肠胚细胞分化谱系
  • 赵冰，南昌大学
  • 邵玥，清华大学
    Human gastroids recapitulate developmental symmetry breaking in early stomach organogenesis
  • 程新，中国科学院分子细胞科学卓越创新中心
    再生胰岛移植治疗胰岛素依赖型糖尿病
基于干细胞产生的类胚胎和类器官是近年来生命科学领域快速发展起来的新兴前沿技术，目的是在体外模拟人体早期胚胎和器官生理特征和功能。其模型广泛应用于组织器官发育、疾病研究、精准医学和新药研发等方面。3D打印、器官芯片等新技术为制备具有特定结构和功能的器官提供了新策略。本分会场聚焦类胚胎与类器官制备的新技术和应用的新进展，邀请全国知名学者及青年PI分享进行交流分享。
Stem cell-based construction of embryoid and organoid is an emerging frontier technology that has been rapidly developed in the field of life sciences in recent years, which aims to simulate the physiological characteristics and functions of human early embryos and organs in vitro. These models are widely used in tissue and organ development, disease research, precision medicine, and new drug development. New technologies, such as 3D printing and organ-chip, provide new strategy for reconstructing organs with specific structures and functions. This session will focus on the new technology of embryoid and organoid construction and the new achievements in applications, recruiting established investigators and rising stars for interactive discussions and exchanges.
召集人

叶丽林
陆军军医大学

刘星
中科院上海免疫与感染研究所

邀请报告人
  • 刘星，中科院上海免疫与感染研究所
    Inflammasome-independent pyroptosis
  • 王雅婷，清华大学
    Redefine the role of autophagy in cell death and inflammation during respiratory infections
  • 韩家淮，厦门大学
  • 李姗，南方科技大学医学院
  • 吕奔，中南大学湘雅二医院
  • 刘翠华，中国科学院微生物研究所
    Host cell death and immune dysregulation in tuberculosis infection
  • 何苏丹，中国医学科学院苏州系统医学研究所
    Cell death-dependent and -independent functions of RIPK3 in modulating immunity
细胞死亡主要包括凋亡、程序性坏死和焦亡等多种形式，在免疫应答中扮演着关键角色。凋亡是一种非炎性的程序性细胞死亡，通过去除不需要或病变的细胞来调节免疫系统；而程序性坏死与焦亡则伴随着细胞膜破裂，激发强烈的炎症反应，介导病原体的清除，同时也可能引发组织损伤。细胞死亡不仅影响免疫细胞功能，还通过释放细胞内物质调节免疫反应。这些机制协同作用，确保免疫系统能够有效应对病原体，同时维持机体的稳态。
Cell death, including forms of apoptosis, necroptosis, and pyroptosis, plays a crucial role in immune responses. Apoptosis is a non-inflammatory form of programmed cell death that typically helps regulate the immune system by removing unwanted or damaged cells. In contrast, necroptosis and pyroptosis involve cell membrane rupture and trigger strong inflammatory responses. While they help eliminate pathogens, they may also cause tissue damage. Cell death not only affects the function of immune cells but also regulates immune responses by releasing intracellular contents. These mechanisms work together to ensure that the immune system effectively combats pathogens while maintaining homeostasis in the body.
召集人

史庆华
中国科学技术大学

赵小阳
南方医科大学

邀请报告人
  • 史庆华，中国科学技术大学
  • 赵小阳，南方医科大学
  • 谭韬，昆明理工大学
  • 童明汉，中国科学院分子细胞科学卓越创新中心
  • 苏俊，北京生命科学研究所
    Degradation of maternal RNA polymerase II is essential for oocyte chromatin reorganization and embryonic development in mammals
  • 高栋，中国科学院分子细胞科学卓越创新中心
  • 胡志斌，南京医科大学
生殖发育与疾病领域主要关注精子发生、卵子发生、胚胎发育、胚胎植入等发育过程及其相关发育异常与阻滞的前沿科学问题，对于解决育龄人群生育问题、提高出生人口质量、促进人类生殖健康和生活质量、推动发育生物学与生殖医学进步具有重大而深远的意义。
近年来，本领域利用单细胞组学新技术、类胚胎与生殖类器官等新型研究模型，在探索配子发生和胚胎发育及其障碍的分子机制、生殖细胞代谢调控和衰老干预新策略、疾病治疗药物筛选等方面取得了较大的进展。本section将邀请我国该领域内知名专家学者介绍最新研究进展、深入探讨对生殖发育调控分子机制的理解、展望生殖发育障碍相关疾病治疗的应用前景，积极推动生殖细胞生物学的学科发展。
The field of reproductive development and diseases primarily focuses on spermatogenesis, oogenesis, embryo development, embryo implantation, and other related processes. It also encompasses the developmental abnormalities and retardation. This field has significant implications for addressing fertility issues in childbearing couples, improving the quality of the new-birth population, promoting human reproductive health and quality of life, as well as advancing progress in developmental biology and reproductive medicine.

In recent years, remarkable advancements have been made in this field regarding our comprehension of molecular mechanisms underlying gametogenesis and embryonic development disorders, the metabolic regulation of germ cell development, novel strategies for reproductive aging intervention, and the drug screening for disease treatment, with the aids of new technologies such as single-cell omics, blastoids, and reproductive organoids.

This section will invite domestic renowned experts and scholars to introduce the latest advances in this area, give their insights into the mechanisms governing reproductive development, and look forward to the potential applications of strategies for disorders related with reproductive development. Ultimately, these efforts will make significant contributions to the advancement of germ cell biology.
召集人

张珞颖
华中科技大学

邀请报告人
  • 张珞颖，华中科技大学
  • 张二荃，北京生命科学研究所
    Mechanism of the circadian oscillation: TTFL and beyond
  • Hirota Tsuyoshi，Nagoya University
  • Eun Young Kim，Ajou University
  • Daisuke Ono，Nagoya University
  • Chunghun Lim，Korea Advanced Institute of Science and Technology
  • 张勇，苏州大学
    Feeding Rhythm and post-translational modification
  • Jaekyoung Kim，Korea Advanced Institute of Science and Technology
这个专题由来自中国、日本、韩国的学者介绍生物节律与睡眠领域的前沿研究，主要侧重点为生物节律与睡眠的分子调控机制，以及相关疾病。
Researchers from China, Japan and Korea will present work at the forefront of circadian rhythm and sleep fields, with a focus on the regulatory mechanism of circadian rhythm and sleep at the molecular level, as well as related diseases.
召集人

刘默芳
中国科学院上海生物化学与细胞生物学研究所

韩敬东
北京大学

邀请报告人
  • 韩敬东，北京大学
    多模态单细胞筛选揭示衰老相关lncRNA的功能及其在细胞衰老中的作用
  • 李华兵，重庆医科大学
    T细胞功能的RNA修饰调控
  • 林爱福，浙江大学
    长链非编码RNA与细胞信号调控
  • 周宇，武汉大学
    Functions and Mechanisms of Sequential Polyadenylation
  • 程红，中国科学院分子细胞科学卓越创新中心
  • 戴鹏，同济大学
    无膜细胞器与3'UTR调控
  • 张强锋，清华大学
    Predicting small molecule and RNA target interactions using deep neural networks
  • 赵方庆，中科院动物所
    基于纳米孔测序的RNA组成及其修饰的解析技术
非编码RNA是由基因组转录产生的一类不同于蛋白质编码mRNA的遗传信息分子，是后基因组时代生命科学最活跃的前沿研究领域之一。近20年来，通过对非编码RNA的发现及功能鉴定，大量证据表明非编码RNA在遗传信息表达和调控中具有极其重要的作用。特别是，对真核细胞中非编码RNA的发掘和功能研究，揭示了一个前所未料的由RNA介导的遗传信息传递方式和表达调控网络，并从一个不同于蛋白质编码基因的角度注释和阐明了基因组的结构与功能，深入揭示了生命活动及遗传与进化的本质，将为人类疾病机理研究及诊治提供新思路和新方法。本分会场将邀请国内外本领域的专家学者一起研讨“非编码RNA在重要生命活动过程中的功能机制”相关的研究体系和前沿性重大进展，展望这一领域的发展方向。
Non-coding RNAs (ncRNAs) are a class of genetic information molecules, which remain one of the most active frontiers in post-genome era. Increasing evidence shows that ncRNAs play critical roles in regulating gene expression at epigenetic, transcriptional and post-transcriptional levels. In particular, functional studies of ncRNAs in eukaryotic cells have uncovered a previously unanticipated RNA-mediated genetic information transmission mode and gene regulation network, which annotate and clarify the structure and function of the genome from a perspective different from protein-coding genes. Recent advances in the field have deepened our understanding of the nature of biological activities, inheritance and evolution, and provided new ideas and new methods for the study of human disease mechanism and diagnosis and treatment. This session will invite domestic experts and scholars in this field to discuss the relevant research system and cutting-edge major progress of "Functional non-coding RNAs in important biological processes", as well as the development direction of this field.
召集人

陈佺
南开大学

陈帅
南京大学

邀请报告人
  • 陈佺，南开大学
  • 陈政，哈尔滨工业大学
    代谢相关RNA结合蛋白整合调控糖脂代谢稳态
  • 甘振继，南京大学医学院
    Tuning skeletal muscle fuel catabolism to alleviate dietary obesity
  • 刘军力，复旦大学
    脂肪组织能量代谢调控
  • 刘兴国，中国科学院广州生物医药与健康研究院
  • 余巍，复旦大学
    Pyruvate kinase activates SARM1 to exacerbate axonal degeneration in diabetic peripheral neuropathy
  • 罗婕，武汉大学
    An ER ubiquitin ligase shapes lysosomal positioning and function in Purkinje cell survival
  • 王琰，武汉大学
    To recycle or to degrade: filling the last gap of PCSK9-mediated LDLR degradation
  • 郑巧霞，北京大学（中国细胞生物学学会-蔡司女科学家基金）
    Ca2+ calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation
代谢物在体内时空维度的调控对于细胞功能、组织发育、生理平衡及疾病发生发展至关重要。这一调控涉及细胞内多个层面的精细协调，细胞如何动态调整代谢网络以应对环境变化、如何维持细胞代谢稳态抗微扰、如何影响细胞生理活动的决策、如何通过代谢信号与邻近甚至远程细胞交互交流，整合多层次的调控机制，进而重编程整体代谢状态，允许细胞代谢网络在时空上实现了动态适应，精细地调控组织稳态。本次会议集结了在细胞代谢时空调控领域有卓越贡献的专家，聚焦议题包括细胞代谢的网络调控、细胞功能的代谢物调控和肿瘤微环境下的代谢调节，本次会议旨在深化对细胞代谢稳态的理解与创新。
The regulation of metabolites in the spatiotemporal dimension within the body is crucial for cell function, tissue development, physiological balance, and the occurrence and progression of diseases. This regulation involves intricate coordination across multiple levels within cells. It addresses how cells dynamically adjust metabolic networks to respond to environmental changes, how they maintain metabolic homeostasis against perturbations, how they influence decisions regarding cellular physiological activities, and how they communicate and interact with nearby or even distant cells through metabolic signaling? This integrates multi-level regulatory mechanisms, reprogramming the overall metabolic state, allowing the metabolic network to dynamically adapt in both time and space, thereby enabling the fine-tuned regulation of organelle homeostasis. This meeting will bring together scientists who have made outstanding contributions in the field of spatiotemporal regulation of cellular metabolism. Topics: network regulation of cellular metabolism, metabolite regulation of cell functions, metabolic regulation in the tumor microenvironment. The goal of this conference is to deepen our understanding and innovation in cellular metabolic homeostasis.
召集人

康铁邦
中山大学

邀请报告人
  • 康铁邦，中山大学
  • 赵永祥，广西医科大学
  • 高平，南方医科大学
    代谢重编程调控肿瘤免疫逃逸的机制
  • 邓艳红，中山大学附属第六医院
    TRIM29 Promotes Liver Metastasis via Enhancing Hepatic Colonization by Stabilizing FAM83H to Regulate Keratin Network in Colorectal Cancer
  • 汪源，四川大学
    肿瘤神经网络重塑和靶向
  • 赵颖，北京大学
  • 刘洪，中南大学湘雅医院
  • 朱鹤，上海交通大学仁济医院
    前列腺癌微环境和肿瘤细胞可塑性
肿瘤是我国人民生命健康的第一大死因，肿瘤的发生发展是一个极其复杂的过程，涉及多因素、多步骤、多基因的相互作用。肿瘤免疫治疗、肿瘤靶向治疗等是当今应用最广的关键治疗策略，其创新的源头来自于肿瘤细胞生物学的多学科、多领域等紧密合作的研究成果。我们的分会场将汇聚全国肿瘤细胞生物学领域精英，围绕“肿瘤免疫治疗、肿瘤靶向治疗”等方面的前沿科学问题，交流最前沿的研究成果，推动学科发展，促进转化研究，为肿瘤防治事业贡献智慧与力量。
Cancer is the leading cause of death in the life and health of Chinese people, and the occurrence and development of cancer is an extremely complex process, involving the interaction of multiple factors, multiple steps and multiple genes. Cancer immunotherapy and cancer targeted therapy are the most widely used key therapeutic strategies today, and the source of their innovation comes from the research results of multidisciplinary and multi-field cooperation in cancer cell biology. Our sub-venues will bring together national elites in the field of cancer cell biology to exchange the most cutting-edge research results on cutting-edge scientific issues such as "tumor immunotherapy and tumor targeted therapy", facilitate the development of disciplines, promote translational research, and contribute wisdom and strength to cancer prevention and treatment.
召集人

吴聪颖
北京大学（中国细胞生物学学会-蔡司女科学家基金）

酒亚明
中国科学院上海免疫与感染研究所

邀请报告人
  • 吴聪颖，北京大学（中国细胞生物学学会-蔡司女科学家基金）
    A proactive role of the nucleus in cancer cell invasion
  • 酒亚明，中国科学院上海免疫与感染研究所
    细胞骨架中间丝的动态调控研究
  • 史岸冰，华中科技大学
    Age-associated decline in RAB-10 efficacy impairs intestinal barrier integrity
  • 梁凯威，武汉大学
    细胞骨架重塑诱导的造血恶性转化
  • 蔡华清，中国科学院生物物理研究所（中国细胞生物学学会-蔡司女科学家基金）
    Dissecting the role of the actin network in macropinosome formation and maturation
  • 狄士傑，香港大学
    Tubulin isotypes can harness the mechanosensitivity of the lattice for microtubule luminal accessibility
  • 李杰婕，北京师范大学
    Host actin remodeling mediates mitochondrial elongation to regulate innate immunity in Arabidopsis
  • 易培珊，四川大学
    Rho家族小G蛋白介导的细胞极性调控苔藓植物形态建成
细胞骨架是细胞器互作和细胞间交流的结构基础，是细胞运动、极性建立、形态发生等重要细胞生物学过程的核心分子机器，在胚胎发育和机体稳态平衡建立和维持等生理过程中发挥重要的作用，是细胞生物学研究的中心领域之一。本分会场聚焦细胞骨架、细胞运动和极性领域最新技术发展和科学发现，邀请全国知名专家学者进行研讨。
Cytoskeleton is the structural basis of organelle interaction and cell-cell communication. It is the key molecular machinary for cell motility，polarity and morphogenesis, playing important roles in embryonic development and physiological homeostasis. Cytoskeleton, cell motility and polarity underlies the core of cell biology studies. This sub-group focuses on the latest technological development and scientific discoveries in the fields of cytoskeleton, cell motility and polarity, and invites experts from related fields to join the discussion.
召集人

徐素宏
浙江大学

黄雨薇
西安交通大学

邀请报告人
  • 徐素宏，浙江大学
    Mechanism for sensing and repairing plasma membrane damage
  • 黄雨薇，西安交通大学
    膜损伤及膜稳定性
  • 邵峰，北京生命科学研究所
  • 王迪，浙江大学
    组织及细胞损伤修复
  • 钟清，上海交通大学
    膜损伤修复
  • 杨崇林，云南大学
    Understanding metabolic damage of mitochondria
  • 俞立，清华大学
    膜动态
  • 方晓峰，清华大学（中国细胞生物学学会-碧云天青年科学家奖获奖者）
    Membrane remodeling by biomolecular condensates
  • 茶歇，
    10:05-10:10 韦峰，锆石光电（苏州）有限公司
    新一代无标记活细胞成像技术原理及其应用
质膜是细胞内外环境的重要屏障，对维持细胞内环境稳态至关重要。破坏其完整性可导致细胞死亡，通常由机械应力、毒素诱导的孔形成或氧化损伤等因素引起。为了对抗这种情况，细胞已经发展出快速有效的机制来修复膜损伤，防止细胞内容物的丢失和有害物质的流入。这些修复过程在暴露于频繁机械应力的细胞(如肌肉细胞)和遇到病原体的免疫细胞中尤其重要。膜修复缺陷与肌肉营养不良和神经退行性疾病等疾病相关。因此，在过去的十年中，关于质膜完整性和修复的研究获得了越来越多的关注，也促进了对内膜系统动态完整性的探索，为进一步理解细胞膜系统奠定了基础。
The plasma membrane is a critical barrier that separates a cell's internal environment from its external surroundings, essential for maintaining cellular homeostasis. Disruptions to its integrity can lead to cell death, often caused by factors like mechanical stress, toxin-induced pore formation, or oxidative damage. To counteract this, cells have developed rapid and efficient mechanisms for repairing membrane damage, preventing the loss of cellular contents and the influx of harmful substances. These repair processes are especially vital in cells exposed to frequent mechanical stress, such as muscle cells, and in immune cells that encounter pathogens. Defects in membrane repair are associated with diseases like muscular dystrophies and neurodegenerative disorders. As a result, research into plasma membrane integrity and repair has gained significant attention over the past decade, which has also promoted the exploration of the dynamic integrity of the endomembrane system, laying a foundation for a deeper understanding of the cellular membrane system.
召集人

祁海
清华大学

曾文文
清华大学

邀请报告人
  • 祁海，清华大学
  • 曾文文，清华大学
  • 周嘉伟，中国科学院上海生命科学研究院
    Slc2a5+ microglia orchestrate phagocytic microglia-mediated amyloid-β clearance
  • 刘光慧，中国科学院动物研究所
  • 肖意传，中国科学院上海营养与健康研究所
    免疫衰老与肿瘤
  • 史鹏，浙江大学
    Butterfly effect: brain immune cells bridge hemodynamic chaos to sympathetic neurons
  • 陈晓颖，清华大学
    Brain-immune communication in Alzheimer's Disease
本次会议旨在研讨免疫系统在个体衰老及退行性疾病中的表征、作用和机制，主要涉及免疫系统的衰老机制、个体衰老中免疫系统的作用、免疫系统与机体多系统的交叉对话机制在衰老和退行性疾病发生发展中的表征与作用机制。通过结合最新的科学发现与临床来源数据，探讨促进免疫健康的新策略及未来治疗的推动方向。
The purpose of this conference is to discuss the characterization, role, and mechanisms of the immune system in individual aging and degenerative diseases. Key topics will include mechanisms of immune aging, the role of the immune system in individual aging, the cross-talk mechanisms between the immune system and multiple body systems in the context of aging and the development of degenerative diseases. By integrating the latest scientific discoveries with clinical data, we aim to explore new strategies to promote immune health and future directions for therapeutic advancements.
召集人

王秀杰
中国科学院遗传与发育生物学研究所

金焰
哈尔滨医科大学

邀请报告人
  • 王秀杰，中国科学院遗传与发育生物学研究所
    From Bioinformatics to Biofabrication
  • 金焰，哈尔滨医科大学
  • 李亦学，广州国家实验室
    人工智能以及大模型在临床医学研究中的应用
  • 曹志伟，复旦大学
    基于单细胞的肺癌TME研究
  • 吴松，深圳大学附属华南医院
    AI-Based Multi-modal Data Fusion and Non-Invasive Early Diagnosis of Bladder Cancer
  • 谢鹭，上海市生物医药技术研究院
    基于蛋白质基因组学的肿瘤新抗原鉴定计算研究与AI辅助筛选
  • 苏建忠，温州医科大学基因组医学研究院
  • 张云鹏，哈尔滨医科大学
以大语言模型为代表的新型人工智能技术的开发与应用为科学研究和疾病诊疗带来了全新范式，已经在蛋白质结构预测等科研领域产生了变革性的推动作用。本专题聚焦基于人工智能方法的生命科学与医学研究，将分享新型人工智能方法在生命健康大数据解析中的应用成果，并探讨大语言模型等人工智能方法在生命健康研究中的应用前景与挑战。
The development and application of new artificial intelligence technologies represented by large language models have brought scientific research as well as disease diagnosis and treatment to a new paradigm, and have revolutionized protein structure prediction and other research fields. This session will focus on artificial intelligence method based life science and medical researches, share the application achievements of new artificial intelligence methods in life science and medical big data analysis, and discusses the perspectives and challenges for the application of large language model and other artificial intelligence methods in life science and medical researches.
召集人

吴立刚
中国科学院分子细胞科学卓越创新中心

程义云
华东师范大学、上海市基因编辑与细胞治疗前沿科学中心

邀请报告人
  • 吴立刚，中国科学院分子细胞科学卓越创新中心
    gRNA dependent and gRNA independent off-target binding activities of dCas13
  • 程义云，华东师范大学、上海市基因编辑与细胞治疗前沿科学中心
    Fluorinated materials for mRNA Delivery
  • 王泽峰，南方科技大学
    TBD
  • 麻锦彪，复旦大学
    TBD
  • 汪阳明，北京大学
    Combining the power of noncoding RNA and genome editing: innovating tools for understanding and treating human diseases
  • 程强，北京大学
    组织和细胞靶向mRNA-LNP递送技术开发及其应用
  • 王育才，中国科学技术大学
    mRNA药物的递送与转化研究
  • 张川，上海交通大学
    自组装核酸水凝胶药物递送系统及其应用
核酸药物作为精准医疗的先锋，可过表达补充功能异常或缺失蛋白，也可沉默或编辑特定基因片段，为遗传病、肿瘤等难治性疾病提供了革命性的治疗策略。本次会议聚焦于核酸药物研发的两个核心议题，即核酸修饰技术和递送系统的创新策略，邀请了核酸修饰与递送领域的杰出专家，旨在搭建一个跨学科、高水平的交流平台，加速核酸药物研发进程，推动前沿成果的转化与应用，促进我国生物医药产业的快速健康发展。
Nucleic acid drugs are at the forefront of precision medicine, offering the potential to restore protein function through overexpression mechanisms in cases of aberrant or missing functionalities, as well as to silence or edit specific gene segments. These approaches open up novel therapeutic pathways for challenging diseases such as genetic disorders and cancer. The upcoming conference focuses on two critical dimensions of nucleic acid drug development: significant progress in nucleic acid modification technologies and innovative strategies for delivery system optimization. To this end, the conference has assembled a distinguished group of experts in the fields of nucleic acid modification and delivery, establishing a cross-disciplinary and high-quality platform for scholarly dialogue. This platform is dedicated to accelerating the research and development process of nucleic acid drugs, promoting the application of cutting-edge scientific discoveries, and fostering the robust and sustainable growth of China’s biomedical industry.
召集人

彭勃
复旦大学

刘妍
南京医科大学

邀请报告人
  • 彭勃，复旦大学
    死亡与新生：关于小胶质细胞的哲学
  • 刘妍，南京医科大学
    Human Brain Assembloids: Human Models for Studying Neurological Diseases
  • 赵春杰，东南大学
    端脑图式形成和不同类型神经元命运的调控
  • 饶艳霞，复旦大学
    Microglial replacement and its application in neurodegenerative disorders
  • 郭兴，南京医科大学
    NEDD4L facilitates metabolic dysfunction and neurodegeneration by promoting LIPT2 degradation in Huntington’s disease
  • 章小清，同济大学
    The developmental origin of human brain and spinal cord at the stage of neurulation
  • 王延江，陆军军医大学大坪医院
    基于骨髓移植的阿尔茨海默病干预
  • 许执恒，中科院遗传发育所
    TAPT1 与 SUCO 互作调控新合成蛋白质的稳态和大脑发育
  • 何丹阳，西湖大学
    Plasticity and function of disease-associated microglia
  • 杨振纲，复旦大学
    大脑皮质胶质发生的基本原理和分子机制
神经元是大脑内信号传递的主体细胞，是大脑功能的主要执行者和信息传递的主要承载者。然而，大脑作为中枢神经系统的一部分，是在多种细胞类型的共同协作下执行功能。除了神经元细胞外，大脑内的非神经元细胞，例如神经干细胞与胶质细胞，都承载着非常重要的功能，对大脑发育、稳态维持和疾病等多个生理和病理进程中起关键作用。长期以来，对大脑中的这类非神经元细胞的研究处于较忽视的地位。然而近十多年来，随着研究手段的发展和技术的进步，人们对神经干细胞与胶质细胞的认识在不断加深，有许多被忽视的重要功能不断被发现，甚至部分曾经被写入教科书的经典观点被改写。神经干细胞与胶质细胞的研究已成为现代神经科学的前沿热点问题。近年来，海内外华人在该领域取得了不少重要研究发现。本研讨会拟结合近两年海内外华人在该领域取得的重要进展，拟邀请章小清、王延江、饶艳霞、何丹阳、赵春杰、许执恒、郭兴、杨振纲、刘妍和彭勃等知名专家，共同开展研讨和交流。从神经干细胞在稳态、衰老和疾病的功能等前沿问题进行深入探讨，旨在促进国内神经科学研究的交流和发展。
Neurons are the main cells and carrier of signal transmission in the brain and the main executor of brain function. However, the brain, as part of the central nervous system, performs its functions under the cooperation of multiple cell types. In addition to neuronal cells, the non-neuronal cells, including neural stem cells and glial cells in the brain carry very important functions and play a key role in multiple physiological and pathological processes such as brain development, homeostasis maintenance and disease pathogenesis. For a long time, the study of such non-neuronal cells in the brain has been neglected. However, in the past decade, with the development of research methods and the progress of technology, people's understanding of neural stem cells and glial cells has been deepened, many neglected important functions have been discovered, and even some classic views that were once written in textbooks have been revised. The research of neural stem cells and glial cells has become a focused topic in modern neuroscience. In recent years, Chinese domestic and overseas have made many important research findings in this field. This seminar plans to give a comprehensive overview of the research findings from Chinese experts domestic and abroad in recent years, and to invite well-known experts such as Zhang Xiao-qing, WANG Yan-jiang, RAO Yanxia, HE Danyang, ZHAO Chun-jie, XU Zhi-heng, GUO Xing, YANG Zhen-gang, LIU Yan and PENG Bo to discuss and communicate with each other. In order to promote the communication and development of neuroscience research in China, this seminar discusses the frontier issues of neural stem cells in homeostasis, aging and disease.
召集人

赵瑚
北京脑科学与类脑研究所

高正良
上海大学医学院

邀请报告人
  • 赵瑚，北京脑科学与类脑研究所
  • 高正良，上海大学医学院
    类器官在人脑发育和疾病模拟中的应用
  • 曹罡，深圳理工大学
    Integrating single cell spatial-omics with connectome
  • 吴江来，北京脑科学与类脑研究所
    面向透明化组织成像的曲面光片显微技术
  • 付志飞，福建医科大学
    A highly stable monomeric red fluorescent protein for advanced microscopy
  • 王红艳，复旦大学
    FBXW4 mutations induced over-degradation of a RNA binding protein CCT5 disrupts the skeletal development
  • 向阳飞，上海科技大学
随着发育学科的发展和技术的进步，新模型和新技术对于发育生物学前沿与突破的推动作用日趋明显。过去十年见证了单细胞分析、多组学，实时、大尺度和高分辨率成像和类器官等新技术的出现和飞速进展，被日益广泛的应用到发育生物学研究，给诸多曾经无从入手的重大发育生物学、稳态与疾病问题的解析带来的全新的路径与可能。时值云发育论坛四周年之际，特邀请相关领域的专家在2025年中国细胞生物学学会年会隆重推出云发育论坛发育与新技术专题分会。
With continuous advances in developmental biology and related technologies, new model systems and technologies play ever more crucial roles pushing forward new developmental biology frontiers. The past decade has witnessed rapid appearance and progresses of new technologies such as single cell analysis, omics, live, large scale and high resolution imaging, and organoids. With the help of these powerful new technologies, we can now start to address some of the most fundamental and challenging questions in the field previously impossible to approach. To celebrate the 4th anniversary of the Developmental Biology iForum, you are cordially invited to attend this Developmental Biology Special topic iForum---"Transforming Technologies", presented by excellent field experts at the 2025 Chinese Society for Cell Biology Annual conference.
召集人

李兵辉
首都医科大学

雷群英
复旦大学

邀请报告人
  • 李兵辉，首都医科大学
    AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress
  • 叶存奇，浙江大学
    Phospholipid biosynthesis as a critical modulator of metabolic homeostasis and efficiency
  • 强力，北京大学
    IgG welds aging and obesity
  • 葛亮，清华大学
    Lipid regulated translocation of versatile cargoes in unconventional secretion
  • 马欣然，华东师范大学
  • 丁秋蓉，中国科学院上海营养与健康研究所
    Liver purine metabolism and dietary lipid absorption
  • 饶枫，南方科技大学
  • 魏民，东北师范大学
    Insights into Redox Balance-implicated Amino Acid Metabolism Regulations in Ferroptosis
  • 王计秋，上海交通大学医学院附属瑞金医院
    大脑调控肠道油脂吸收
代谢物在体内时空维度的调控对于细胞功能、组织发育、生理平衡及疾病发生发展至关重要。这一调控涉及细胞内多个层面的精细协调，细胞如何动态调整代谢网络以应对环境变化、如何维持细胞代谢稳态抗微扰、如何影响细胞生理活动的决策、如何通过代谢信号与邻近甚至远程细胞交互交流，整合多层次的调控机制，进而重编程整体代谢状态，允许细胞代谢网络在时空上实现了动态适应，精细地调控组织稳态。本次会议集结了在细胞代谢时空调控领域有卓越贡献的专家，聚焦议题包括细胞代谢的网络调控、细胞功能的代谢物调控和肿瘤微环境下的代谢调节，本次会议旨在深化对细胞代谢稳态的理解与创新。
The regulation of metabolites in the spatiotemporal dimension within the body is crucial for cell function, tissue development, physiological balance, and the occurrence and progression of diseases. This regulation involves intricate coordination across multiple levels within cells. It addresses how cells dynamically adjust metabolic networks to respond to environmental changes, how they maintain metabolic homeostasis against perturbations, how they influence decisions regarding cellular physiological activities, and how they communicate and interact with nearby or even distant cells through metabolic signaling? This integrates multi-level regulatory mechanisms, reprogramming the overall metabolic state, allowing the metabolic network to dynamically adapt in both time and space, thereby enabling the fine-tuned regulation of organelle homeostasis. This meeting will bring together scientists who have made outstanding contributions in the field of spatiotemporal regulation of cellular metabolism. Topics: network regulation of cellular metabolism, metabolite regulation of cell functions, metabolic regulation in the tumor microenvironment. The goal of this conference is to deepen our understanding and innovation in cellular metabolic homeostasis.
召集人

王平
同济大学

邀请报告人
  • 张令强，军事医学科学院
    RNF111 governs APC/C condensates to regulate chromosomal instability in cancer
  • 焦宇辰，医科院肿瘤医院
  • 侯晋，海军军医大学
    肿瘤化免联合治疗新方案的探索
  • 钟波，武汉大学
    KRAS oncogenic mutants hijack USP25 to evade RNF31-mediated linear ubiquitination and promote non-small cell lung cancer progression
  • 许川，成都电子科大
  • 李磊，华东师范大学
    Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancer models
  • 周鹏辉，中山大学肿瘤防治中心
    实体肿瘤细胞治疗
  • 吴旭东，天津医科大学
    新型表观遗传靶向治疗策略
肿瘤是我国人民生命健康的第一大死因，肿瘤的发生发展是一个极其复杂的过程，涉及多因素、多步骤、多基因的相互作用。肿瘤免疫治疗、肿瘤靶向治疗等是当今应用最广的关键治疗策略，其创新的源头来自于肿瘤细胞生物学的多学科、多领域等紧密合作的研究成果。我们的分会场将汇聚全国肿瘤细胞生物学领域精英，围绕“肿瘤免疫治疗、肿瘤靶向治疗”等方面的前沿科学问题，交流最前沿的研究成果，推动学科发展，促进转化研究，为肿瘤防治事业贡献智慧与力量。
Cancer is the leading cause of death in the life and health of Chinese people, and the occurrence and development of cancer is an extremely complex process, involving the interaction of multiple factors, multiple steps and multiple genes. Cancer immunotherapy and cancer targeted therapy are the most widely used key therapeutic strategies today, and the source of their innovation comes from the research results of multidisciplinary and multi-field cooperation in cancer cell biology. Our sub-venues will bring together national elites in the field of cancer cell biology to exchange the most cutting-edge research results on cutting-edge scientific issues such as "tumor immunotherapy and tumor targeted therapy", facilitate the development of disciplines, promote translational research, and contribute wisdom and strength to cancer prevention and treatment.
召集人

郝捷
中国科学院动物研究所

彭耀进
北京干细胞与再生医学研究院

邀请报告人
  • 郝捷，中国科学院动物研究所
    数据驱动下标准化干细胞资源库的建设与思考
  • 彭耀进，北京干细胞与再生医学研究院
    Data Sharing and Security Challenges in Stem Cell Research
  • 林戈，中南大学
    人胚胎干细胞库的建设与共享
  • 李鑫，中国科学院动物研究所
  • 赵文明，国家生物信息中心
    The GSA family in 2025: A broadened sharing platform for multi-omics and multimodal data
  • 郑厚峰，苏州大学附属第二医院
    亚洲人群单体型参考基因组构建
  • 叶凯，西安交通大学
    人工智能赋能的基因组结构变异检测算法
  • 张国庆，中国科学院上海营养与健康研究所
    生物医学数据的规范化集成与智能治理
  • 茶歇，
    15:05-15:10 周尧，安理（北京）仪器有限公司
    3Dimager智能化成像分析系统助力干细胞和类器官资源库标准化建设
干细胞资源和数据的规范化共享与应用，作为生物医学领域的核心议题。干细胞资源的高效收集、存储、管理、共享以及确保其数据的质量和精确性至关重要。随着人工智能（AI）技术的不断进步和高质量数据的不断积累，干细胞研究和应用正步入一个快速发展的新阶段。本专题将深入探讨干细胞资源库的构建与管理、干细胞资源及数据的标准化流程、干细胞在多样化应用场景中的利用，以及伦理与法律问题的深入分析。此外，还将讨论人工智能在干细胞基础研究和转化应用中的策略，这些议题的深入讨论不仅将推动干细胞科学研究的进展，还将促进其在临床应用中的标准化，为面向人民生命健康的科技创新发展贡献力量。
Stem cell resources and data standardization sharing and application are core issues in the field of biomedicine. Efficient collection, storage, management, sharing of stem cell resources, and ensuring the quality and accuracy of their data is crucial. With the continuous advancement of artificial intelligence (AI) technology and the accumulation of high-quality data, stem cell research and applications are entering a new phase of rapid development. This special topic will delve into the construction and management of stem cell resource centers, standardized processes for stem cell resources and data, the utilization of stem cells in diverse application scenarios, and an in-depth analysis of ethical and legal issues. Additionally, strategies for AI in basic stem cell research and translational applications will be discussed. In-depth discussions on these topics will not only promote the progress of stem cell scientific research but also facilitate the standardization of their clinical applications, contributing to the development of scientific and technological innovation aimed at the health of the human.
召集人

姜恺
武汉大学

温文玉
复旦大学

邀请报告人
  • 姜恺，武汉大学
    New insights into the assembly of microtubules at the spindle and centriole
  • 温文玉，复旦大学
    Targeting redox-sensitive MBD2-NuRD condensate for tumor therapy
  • 高宁，北京大学
    Stomatin is a scaffold protein for membrane microdomains involved in cell migration
  • 李栋，清华大学
    多维高时空分辨显微成像技术开发进展与应用
  • 刘郑，武汉大学
    “点亮”动态的细胞力学信号：从亚细胞至单分子
  • 何康敏，中国科学院遗传与发育生物学研究所（中国细胞生物学学会-碧云天青年科学家奖入围者）
    Clathrin-associated carriers enable recycling through a kiss-and-run mechanism
  • 田烨，中国科学院遗传与发育生物学研究所
    神经调控线粒体应激及机体衰老
  • 沈义栋，中国科学院分子细胞科学卓越创新中心
    血-脑脊液屏障的衰老机制研究
  • 米达，清华大学
    大脑皮层抑制性神经元多样性的发育起源
近年来，在新研究方法、研究工具与研究思路引领下，细胞生物学的不同领域不断涌现出有关细胞新结构与新行为的发现。本分会场拟以“细胞的新结构与新行为”为主题，打破以单一研究方向或研究范式为主题的分会场模式，邀请细胞生物学不同领域内专家。报告的主题既包含经典细胞生物学，也包括与细胞生物学紧密关联的亚细胞结构生物学、发育生物学、神经生物学、代谢生物学、生物光子学与单分子力学等。我们希望通过该分会场让与会听众了解不同领域的多学科交叉前沿成果。
Recent advancements in research methodology, tools, and concepts have led to the discovery of previously unknown cell structures and processes across the field of cell biology. The proposed session, themed "Novel Cellular Structures and Processes" is designed to transcend singular research directions and paradigms by convening experts from diverse fields of cell biology. The session will encompass topics ranging from classical cell biology to subcellular structural biology, developmental biology, neurobiology, metabolic biology, biophotonics, and single-molecule force spectroscopy, all closely intertwined with cell biology. The primary objective is to engage a varied audience in comprehending the latest pioneering research across a multitude of disciplines and fields.
召集人

吴嘉敏
清华大学

周仁杰
香港中文大学

邀请报告人
  • 吴嘉敏，清华大学
    Mesoscale intravital fluorescence microscopy
  • 周仁杰，香港中文大学
    Coherence-gated optical diffraction tomography for label-free volumetric imaging of cells in thick tissues
  • 席鹏，北京大学
    多维结构光超分辨与转盘共聚焦
  • 李博，复旦大学
    用于活体钙成像的深层三光子和超大视场双光子显微镜
  • 费鹏，华中科技大学
    AI光场成像及细胞生物学应用
  • 章永登，西湖大学
    Elucidating subcellular architecture and dynamics with super-resolution microscopy
  • 徐平勇，中国科学院生物物理研究所
  • 潘雷霆，南开大学
    自动原位免疫荧光超分辨成像及其拓展钙荧光成像
光学显微成像是生物医学研究的重要手段，近年来，光学显微成像领域发展迅速，为推动生命科学原创发现做出了重要的贡献。为了深入交流和探讨光学显微成像在细胞生物学前沿进展与未来发展趋势，我们特举办“显微技术前沿进展”分会场。本届会议将邀请在显微成像领域有着深入研究的知名专家进行报告，介绍多种不同类型显微成像技术的前沿进展，推动先进显微成像技术在细胞生物学研究的广泛应用。
Optical microscopy is a crucial tool in biomedical research, and in recent years, the field has developed rapidly, making significant contributions to original discoveries in life sciences. To facilitate in-depth exchange and discussion on the latest advancements and future trends in optical microscopy, particularly in cell biology, we are organizing a session on "Advances in Microscopy Technology." This conference will invite renowned experts with extensive research in the field of microscopy to present reports, introduce cutting-edge developments in various types of microscopy techniques, and promote the widespread application of advanced microscopy technologies in cell biology research.
召集人

黄俊
浙江大学

许兴智
深圳大学

邀请报告人
  • 黄俊，浙江大学
    R-loop Resolution and Its Impact on Genome Stability
  • 许兴智，深圳大学
    Development of anti-cancer small molecules targeting UFMylation
  • 袁健，同济大学
    Metabolic regulation of homologous recombination repair by MRE11 lactylation
  • 彭斌，深圳大学
    Molecular crowbar targeting MRN complex for radiosensitization
  • 丛羽生，杭州师范大学
    UFMylation deficiency in hepatocytes causes liver diseases through activation of the Keap1-Nrf2 pathway
  • 石磊，天津医科大学
    RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity
  • 甘海云，中国科学院深圳先进技术研究院
    DNA损伤应答维持染色体外环形DNA（ecDNA）的稳定
翻译后修饰（PTM）是维持基因组稳定性和完整性的核心调控机制，一旦基因组稳定性和完整性被破坏，就会促进肿瘤发生，并成为癌症治疗的靶点。在过去二十年中，已经发现了数百种新型 PTMs，其中代谢产物和新发现的泛素样蛋白--泛素折叠修饰因子 1（UFM1）的修饰正在成为调节基因组稳态的新手段。本分会场将主要讨论 UFM1 修饰和糖酵解/三羧酸循环/脂质衍生的 PTMs 如何调控 DNA 损伤修复、DNA 复制和复制应激反应，以及如何开发针对这些 PTMs 的先导化合物。
Post-translational modifications (PTMs) are the core regulatory mechanism for the maintenance of genome stability and integrity, which, when destabilized, promotes tumorigenesis and serves as cancer therapeutic targets. Hundreds of novel PTMs have been identified in the past couple decades, among which modifications by metabolites and ubiquitin-fold modifier 1 (UFM1), the newly-identified ubiquitin-like protein, are emerging to modulate genome homeostasis. This session will mainly discuss how UFM1 modification and glycolysis/Kerbs cycle/lipid-derived PTMs regulate DNA damage repair, DNA replication and replication stress response, and how the lead compounds targeting these PTMs are being developed.
召集人

费继锋
广东省人民医院

焦保卫
中国科学院昆明动物研究所

邀请报告人
  • 费继锋，广东省人民医院
    Establishing efficient Nitroreductase-mediated target cell ablation in the axolotl to reveal the entire cortex regeneration
  • 熊敬维，北京大学分子医学研究所
    化学小分子组合5SM调控心脏外皮-心肌信号及心脏再生
  • 惠利健，中国科学院分子细胞科学卓越创新中心
    Cell Identity Conversion: Liver Regeneration and Cell Therapy
  • 李汉杰，中国科学院深圳先进院
    人体免疫细胞的发育分化与功能
  • 王伟，北京生命科学研究所
  • 裴唯珂，西湖大学
    Single-cell lineage tracing reveals cell fate and mammalian development
  • 韩佩东，浙江大学医学院
  • 张超，中国科学院昆明动物研究所
    Spatial transcriptomics reveals the cellular atlas and spatial organization of the mouse prefrontal cortex
组织器官再生是近年来细胞生物学研究最为活跃的领域之一。器官再生是由损伤所诱导的有步骤的程序性器官重建，具有其特殊；同时，再生利用了器官发育过程中的的多种分子细胞学机制。成功的组织器官再生涉及再生启动、干细胞诱导激活及增殖、分化、模式重建及再生终止等重要步骤，是多种细胞类型及分子信号通路的精确协同调控。新细胞类型的起源是理解生命发育和疾病发生的关键基础：单细胞生命演化为多细胞生命，受精卵发育为生物个体，干细胞分化为组织器官，细胞恶性增殖导致为肿瘤等各种重要生命事件归根结底是新细胞类型的产生造成的。本专题涵盖了多个物种、多种器官再生与起源过程中分子细胞学机制的深入解析、以及基于机制研究的器官再生的应用探索。本专题论坛邀请国内组织器官再生与起源研究领域的专家学者，与各位同仁共同探讨该领域的最新进展。
Organ and tissue regeneration has emerged as one of the most active fields in cellular biology in recent years. Organ regeneration is a stepwise and highly regulated process initially induced by injury. Despite its distinct context, organ regeneration employs many molecular and cellular pathways also involved in organ development. Successful regeneration requires the precise coordination of key stages: initiation, activation of stem cells, proliferation and differentiation, tissue patterning, and the termination of the regenerative process. Each phase relies on the intricate interplay of diverse cell types and molecular signaling pathways. The origin of new cell types is a fundamental basis for understanding the development of life and the pathogenesis of diseases. Critical life events, such as the evolution of unicellular life into multicellular organisms, the development of a fertilized egg into a biological individual, the differentiation of stem cells into tissues and organs, and malignant cell proliferation leading to tumors, ultimately result from the emergence of new cell types. This section focuses on the in-depth of molecular and cellular mechanisms underlying regeneration and origin processes across multiple species and various organs, as well as the exploration of regenerative applications based on mechanistic research. Experts in the field of organ origin and regeneration have been invited to this forum to share their latest researches and discuss the progresses in this field.
召集人

管吉松
上海科技大学

高尚邦
华中科技大学

邀请报告人
  • 管吉松，上海科技大学
    Ash1l-expressing microglia modulates social preference
  • 高尚邦，华中科技大学
    旁抑制神经网络维持运动稳定
  • 周煜东，浙江大学
    Neuroimmune mechanisms of brain disorders
  • 沈伟，上海科技大学
    Zona Incerta neurons control binge eating and compulsive eating
  • 熊伟，中国科技大学
    学习灵活性的神经代谢调控机制
  • 王鑫，厦门大学
    催产素分泌调控的分子机制
  • 潘玉峰，东南大学
    Sexually Dimorphic neural circuit and neuromodulation for innate behaviors in Drosophila
  • 吴青峰，中国科学院遗传发育研究所
    Identification of a neural basis for energy expenditure in the arcuate hypothalamus
  • 徐和平，西湖大学（中国细胞生物学学会-碧云天青年科学家奖获奖者）
    Neuron-immune cell crosstalk in intestinal health and disease
神经细胞是细胞进化史上最重要、最复杂且最具趣味的细胞之一。它既承载着人类高级认知功能，如学习和记忆等，又负责感知所有的外界信息，并协调复杂的运动反馈。然而，目前我们对其细胞功能机制的了解仍较为浅薄。例如，神经细胞在不同维度上如何协调环境与行为的关系，从分子、细胞到神经网络层级，如何有效构建并满足我们不同的生理需求等问题，仍有待深入探索。此外，神经系统疾病的致病机理在细胞水平上的研究，以及如何通过新技术、新手段干预神经细胞活性紊乱带来的挑战，都是全球重大科学难题。围绕这些问题，近年来海内外科学家在该领域取得了重要发现。本次研讨会拟邀请周煜东、王鑫、熊伟、沈伟、潘玉峰、吴青峰等在该领域取得重要进展的著名科学家，就神经细胞细胞功能特征、学习与记忆原理，以及感觉运动疾病的功能变化等前沿问题与全国同仁展开研讨，旨在促进国内神经功能研究的发展。
The nerve cell is one of the most important, complex and interesting cells in the history of cell evolution. It carries advanced cognitive functions, such as learning and memory, and is responsible for sensing all external information and coordinating complex motor feedback. However, our understanding of the mechanisms of its cellular functions is still relatively poor. For example, how nerve cells coordinate the relationship between environment and behavior in different dimensions, and how to effectively construct and meet our different physiological needs from the molecular, cellular to neural network levels still need to be explored in depth. In addition, the study of the pathogenic mechanism of neurological diseases at the cellular level, as well as how to intervene in the challenges posed by disorders of neural cell activity through new technologies and means, are all major global scientific challenges. Focusing on these issues, scientists at home and abroad have made important discoveries in this field in recent years. This symposium intends to invite Zhou Yudong, Wang Xin, Xiong Wei, Shen Wei, Pan Yufeng, Wu Qingfeng, and other famous scientists who have made important progress in this field, to discuss with colleagues across China on the cutting-edge issues of neuronal characterization, learning and memory, and the functional changes in sensory-motor disorders, with the aim of promoting the development of the study of neural function in China.
召集人

余发星
复旦大学

孙书国
华中科技大学

邀请报告人
  • 余发星，复旦大学
    The Hippo pathway in organ size control
  • 孙书国，华中科技大学
  • 张雷，上海交通大学
  • 陈策实，昆明医科大学
    KLF5 phase separation promotes target gene transcription and cell cycle progression
  • 林琳，中国科学院分子细胞科学卓越创新中心
    Decoding signaling in cell fate decisions within multicellular organoid systems
  • 周兆才，复旦大学
    Hippo信号通路调控的功能机制
  • 王作云，复旦大学
    Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis
  • 张宏权，北京大学
For over two decades, the Hippo signaling pathway has been a focal point of scientific research due to its critical role in regulating cell proliferation, cell death, and cell differentiation. This pathway is pivotal in tissue development and organ size control. Disruptions in Hippo signaling can lead to various pathological conditions, including tissue degeneration and cancer. The regulation of the Hippo pathway is influenced by numerous factors such as cell-cell contact, cell polarity, mechanical cues, growth factors, and cellular energy status. This meeting will convene leading experts in the field to discuss the latest advancements in our understanding of the regulation and function of the Hippo pathway.
二十多年来，Hippo 信号通路一直是科学研究的焦点，因为它在细胞增殖、细胞死亡和细胞分化等方面发挥至关重要的作用。Hippo信号通路调节组织发育和器官尺寸，其紊乱可能导致多种病理状况，包括组织退化和癌症。Hippo 信号通路受到多种生理信号影响，如细胞间接触、细胞极性、机械信号、生长因子和细胞能量状态等。本次会议将汇聚该领域的顶尖专家，共同探讨我们对 Hippo 信号通路调控和功能的最新研究进展。

会务组联系方式

联系电话

注册：021-64221860，张老师
学术：021-64221776，季老师
招商：021-64221860，苏老师
奖项：021-64220263，朱老师
财务：021-64220196，吴老师
住宿：13381695656， 王老师

电子邮箱

会务：meeting@cscb.org.cn
财务：treasure@cscb.org.cn

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