雷群英 (中国细胞生物学学会创新奖——杰出成就奖获得者)

教授
复旦大学

报告题目：BCAA-BCKA Sensing beyond mTOR Signaling

2002年获复旦大学上海医学院生物化学与分子生物学专业博士学位。2002至2006年在美国加州大学洛杉矶分校博士后研究， 2006年加入复旦大学上海医学院。长期以胰腺癌为主要模型，聚焦肿瘤发生的代谢起因，取得系列原创成果：揭示了肿瘤高度异质性的代谢内因，提出了胰腺癌的代谢起源假说以及肿瘤早期诊疗的代谢靶向干预新策略，尤其是在支链氨基酸（BCAA）代谢调控肿瘤早期发生领域形成了自己的研究特色；揭示了代谢物（营养组分）及酶可调控细胞表观遗传和翻译后修饰，凸显了代谢物可充当信号分子，为代谢感知调控肿瘤（细胞）生长奠定理论基础。相关研究成果在Nat Cell Biol，Cancer Cell等国际重要学术期刊发表，多次受到Nature、Nat Cell Biol等杂志专题评述或亮点介绍，选为中国高被引学者，受邀在Nat Cell Biol，Nat Metab, Trends Cell Biol及J Biol Chem等发表评述/综述。 

此外，雷群英教授也是新基石研究员、国家杰出青年科学基金获得者、长江特聘教授和万人计划科技创新领军人才，先后担任科技部973项目和重点基础研发项目首席科学家、基金委重大项目和创新群体项目负责人、上海市细胞生物学会副理事长、中国细胞生物学学会常务理事和细胞代谢分会会长。获中国青年女科学家奖、上海市自然科学一等奖、谈家桢生命科学创新奖、吴阶平-保罗·杨森医学药学奖和全国三八红旗手等荣誉。

Prof. Qun-Ying Lei obtained her Ph.D.in Shanghai Medical College, Fudan University, China in 2002, and completed her postdoctoral training in University of California, Los Angeles, CA. In 2006, she moved back to China and joined Shanghai Medical College, Fudan University. Prof. Lei is now the New Cornerstone Investigator and a senior PI working in Shanghai Cancer Center and Institute of Biomedical Sciences and the Dean of School of Basic Medical Sciences, Fudan University, China. Prof. Lei’s laboratory focuses on nutrition and cancer metabolism to understand the metabolic plasticity, specifically defining translational significance of metabolic therapy/intervention in pancreatic ductal adenocarcinoma (PDAC). Her research work have been published in Nat Cell Biol, Nat Metab, Cancer Cell, Cell Metab, Mol Cell, J Clin Invest, as well as other Peer-Reviewed journals. Due to her elegant work, she has received various honors and awards including Wu Jieping - Paul Janssen Medical & Pharmaceutical award(2021), C.C.Tan Life Science Innovation Award (2020), Chinese Young Women in Science Awards (2013), and others. 

Recent 5 year’ Selected Publications:(* indicated as corresponding author)

1. Li ML, Cao SY, Qu J, Zhang L, Gao Q, Wang X, Yin M, Liu Y, Lei MZ*, Lei QY*. S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiency. Development. 2023;150(20):dev201135.
2. Qian L#, LiN#, Lu XC#, Xu MD#, Liu Y, Li KY, Zhang Y, Hu KW, Qi YT, Yao J, Wu YL, Wen WY, Huang SL, Chen ZJ, Yin M, Lei QY*. Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression. Nature Metabolism, 2023;5(7):1159-1173
3. Ma QX#, Zhu WY, Lu XC, Jiang D, Xu F, Li JT, Zhang L, Wu YL, Chen ZJ, Yin M*, Huang HY*, Lei QY*. BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16. Nature Metabolism. 2022;4 (1), 106-122. (Highlight by Nature Reviews Endocrinology)
4. Huang W#, Li N#, Zhang Y, Wang X, Yin M, Lei QY*. AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner. Autophagy. 2022;18(2):309-319.
5. Pei X, Li KY, Shen Y, Li JT, Lei MZ, Fang CY, Lu HJ, Yang HJ, Wen W, Yin M, Qu J, Lei QY*. Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth. Sci China Life Sci. 2022; 65(10):2017-2030.
6. Li JT#, Li KY#, Su Y, Shen Y, Lei MZ, Zhang F, Yin M, Chen ZJ, Wen WY, Hu WG, Su D*, Qu J*, Lei QY*. Diet High in Branched-chain Amino Acid Promotes PDAC Development by USP1-mediated BCAT2 Stabilization. National Science Review. 2021 Nov 26;9(5): nwab212.
7. Li JT#, Yin M#, Wang D#, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY*. BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma. Nature Cell Biology 2020;22(2):167-174. (Highlight by Nature Cell Biology)
8. Lei MZ, Li XX, Zhang Y, Li JT, Zhang F, Wang YP, Yin M, Qu J*, Lei QY*. Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth. Signal Transduct Target Ther. 2020 May 29;5(1):70.
9. Liu Y#, Guo JZ#, Liu Y#, Wang K, Ding WC, Wang H, Liu X, Zhou ST, Lu XC, Yang HB, Xu CY, Gao W, Zhou L, Wang YP, Hu WG, Wei YQ, Huang CH*, Lei QY*. Nuclear Lactate Dehydrogenase A Senses ROS to Produce α-Hydroxybutyrate for HPV-Induced Cervical Tumor Growth. Nature Commun. 2018, 9(1).
10. Zhong XY, Yuan XM, Xu YY, Yin M, Yan WW, Zou SW, Wei LM, Lu HJ, Wang YP*, Lei QY*. CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer. Cell Reports, 2018, 24(12): 3207-3223.