刘颖

北京大学博雅特聘教授、未来技术学院副院长、新基石研究员

报告题目：Decoding Amino Acid Sensing: Molecular Machinery and Mechanisms

刘颖，北京大学博雅特聘教授、未来技术学院副院长、新基石研究员。2006年本科毕业于南京大学生物化学系，2011年获得美国德克萨斯大学西南医学中心生物化学博士学位，2011-2013年在美国麻省总医院和哈佛大学医学院从事博士后研究。2013年12月至今在北京大学分子医学研究所（现未来技术学院）先后任tenure track助理教授、长聘副教授和正教授。

长期从事代谢和衰老的相关研究，尤其关注细胞对于营养物质信息的感知机制和线粒体损伤的应激机制，1）发现新的亮氨酸感知蛋白SAR1B，以及介导细胞感应氨基酸和葡萄糖水平的新机制，揭示了相关蛋白在糖脂代谢稳态调控、癌症发生和衰老进程中的重要作用。2）提出了线粒体监察的新概念，并在细胞、组织和个体水平上系统解析了线粒体胁迫和能量匮乏的感应机制。

曾入选美国霍华德·休斯医学研究所（HHMI）国际研究学者、国家杰出青年科学基金获得者和万人计划科技创新领军人才，担任Molecular Cell杂志Advisory board成员，中国细胞生物学学会细胞代谢分会副会长和细胞器分会副会长。获首届科学探索奖、中国青年女科学家奖、谈家桢生命科学创新奖和全国三八红旗手等荣誉。

Ying Liu is a Boya Distinguished Professor at Peking University, Vice Dean of the College of Future Technology, and a New Cornerstone Investigator. She earned her Bachelor's degree in Biochemistry from Nanjing University in 2006 and completed her Ph.D. in Biochemistry at the University of Texas Southwestern Medical Center in 2011. From 2011 to 2013, she conducted postdoctoral research at Massachusetts General Hospital and Harvard Medical School. Since December 2013, she has been a faculty member at the Institute of Molecular Medicine (now part of the College of Future Technology) at Peking University, where she has held the positions of tenure-track assistant professor, associate professor, and full professor. Her research focuses on metabolism and aging, with particular emphasis on the mechanisms by which cells sense nutrient signals and respond to mitochondrial stress. 1) She discovered a novel leucine sensor, SAR1B, and identified new mechanisms by which cells detect amino acid and glucose levels, revealing the crucial roles of these proteins in regulating glucose and lipid metabolism, cancer development, and aging. 2) She introduced the concept of mitochondrial surveillance and has systematically investigated the mechanisms by which cells, tissues, and organisms sense mitochondrial stress and energy deprivation.

She has been recognized as an International Research Scholar by the Howard Hughes Medical Institute (HHMI) and as a recipient of the National Outstanding Young Scientist Fund. She serves on the Advisory Board of Molecular Cell. In addition, she has received several honors, including the inaugural Xplorer Prize, the China Youth Female Scientist Award, the Tan Jiazhen Life Science Innovation Award, and others.

Selected Publications Over the Past 5 Years: ( *indicates corresponding author)

1. Zhou L, Jiang L, Li L, Ma C, Xia P, Ding W, Liu Y* (2024). A germline-to-soma signal triggers an age-related decline of mitochondrial stress response. Nature Communications 8;15(1):8723.
2. Yan G, Yang J, Li W, Guo A, Guan J, Liu Y*; Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing, Nature Cell Biology (2023) 25(5):754-764.
3. Xu C#, Pan X#, Wang D, Guan Y, Yang W, Chen X*, Liu Y* (2023). O-GlcNAcylation of Raptor transduces glucose signals to mTORC1. Molecular Cell 83(16):3027-3040.
4. Zhao T, Guan Y, Xu C, Wang D, Guan J, Liu Y* (2023). VWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes. Nature Communications 20;14(1):8464.
5. Zhang J#, Peng Q#, Ma C#, Wang J#, Xiao C, Li T, Liu X, Zhou L, Zhou W, Ding W, An N, Zhang L, Liu Y* and Li C-Y* (2023). 6mA-Sniper: Quantifying 6mA Sites in Eukaryotes at Single-Nucleotide Resolution. Science Advances 20;9(42):eadh7912.
6. Ma C#, Xue T#, Peng Q#, Zhang J, Guan J, Ding W, Li Y, Xia P, Zhou L, Zhao T, Wang S, Quan L, Li C-Y*, Liu Y*. A novel N6-Deoxyadenine methyltransferase METL-9 modulates C. elegans immunity via dichotomous mechanisms. Cell Research (2023) 33(8):628-639.
7. Wang D#, Xu C#, Yang W, Chen J, Ou Y, Guan Y, Guan J, Liu Y*; E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Molecular Cell (2022) 82(4):770-784.
8. Chen J#*, Ou Y#, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen P, Liu Y*; SAR1B senses leucine levels to regulate mTORC1 signalling. Nature (2021) 596(7871):281-284.
9. Li Y, Ding W, Li C-Y and Liu Y*. HLH-11 modulates lipid metabolism in response to nutrient availability. Nature Communications (2020) 11:5959.
10. Shao L#, Peng Q#, Dong M, Gao K, Li YM, Li Y, Li C-Y* and Liu Y*. Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity. Nature Communications (2020) 11:4639.